Early Career Investigator Commentary| Volume 88, ISSUE 9, e41-e43, November 01, 2020

Shared Versus Disorder-Specific Brain Morphometric Features of Major Psychiatric Disorders in Adulthood

      SEE CORRESPONDING ARTICLE ON PAGE 678 Diagnosis, the process of classification of disorders, has been fundamental to clinical practice and research in psychiatry. Psychiatric neuroscience has relied on diagnostic classification systems to understand the biological mechanisms underlying specific disorders and to better support disease prevention and treatment (
      • Linden D.E.
      The challenges and promise of neuroimaging in psychiatry.
      ). However, as the number and sample sizes of neuroimaging studies have grown, meta-analyses of neuroimaging data have begun to reveal two points in psychiatric neuroscience: 1) there is notable overlap in the identified abnormalities between individuals with psychiatric disorders and typically developing control subjects, and 2) identifying shared versus disorder-specific neurobiological features of psychiatric illness is critical for supporting preventive and therapeutic efforts in psychiatry. Specifically, understanding shared versus disorder-specific regional dysfunction may advance the understanding of pathophysiologic processes underlying specific disorders as well as processes underlying constructs that are common to several different conventionally defined psychiatric disorders, facilitate the discovery of neural markers for illness trajectory, and enhance the development of therapeutics.
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