Advertisement

Integrative Genomics for the Interpretation of Genetic Loci Implicated in Neurodevelopmental Disorders

  • Rebecca L. Walker
    Correspondence
    Address correspondence to Rebecca L. Walker, Ph.D., Broad Institute of MIT and Harvard, 415 Main St, Cambridge, MA 02142.
    Affiliations
    Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California

    Broad Institute of MIT and Harvard, Cambridge, Massachusetts
    Search for articles by this author
      SEE CORRESPONDING ARTICLE ON PAGE 470
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Geschwind D.H.
        • Flint J.
        Genetics and genomics of psychiatric disease.
        Science. 2015; 349: 1489-1494
        • Gandal M.J.
        • Leppa V.
        • Won H.
        • Parikshak N.N.
        • Geschwind D.H.
        The road to precision psychiatry: Translating genetics into disease mechanisms.
        Nat Neurosci. 2016; 19: 1397-1407
        • Ward L.D.
        • Kellis M.
        Interpreting noncoding genetic variation in complex traits and human disease.
        Nat Biotechnol. 2012; 30: 1095-1106
        • GTEx Consortium
        Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans.
        Science. 2015; 348: 648-660
        • Wang D.
        • Liu S.
        • Warrell J.
        • Won H.
        • Shi X.
        • Navarro F.C.P.
        • et al.
        Comprehensive functional genomic resource and integrative model for the human brain.
        Science. 2018; 362eaat8464
        • Parikshak N.N.
        • Luo R.
        • Zhang A.
        • Won H.
        • Lowe J.K.
        • Chandran V.
        • et al.
        Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism.
        Cell. 2013; 155: 1008-1021
        • O’Brien H.E.
        • Hannon E.
        • Hill M.J.
        • Toste C.C.
        • Robertson M.J.
        • Morgan J.E.
        • et al.
        Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders.
        Genome Biol. 2018; 19: 1-13
        • Walker R.L.
        • Ramaswami G.
        • Hartl C.
        • Mancuso N.
        • Gandal M.J.
        • de la Torre-Ubieta L.
        • et al.
        Genetic control of expression and splicing in developing human brain informs disease mechanisms.
        Cell. 2019; 179: 750-771
        • Hammerschlag A.R.
        • Byrne E.M.
        • Bartels M.
        • Wray N.R.
        • Middeldorp C.M.
        • eQTLGen Consortium
        • BIOS Consortium
        Refining attention-deficit/hyperactivity disorder and autism spectrum disorder genetic loci by integrating summary data from genome-wide association, gene expression, and DNA methylation studies.
        Biol Psychiatry. 2020; 88: 470-479
        • Liao C.
        • Laporte A.D.
        • Spiegelman D.
        • Akçimen F.
        • Joober R.
        • Dion P.A.
        • Rouleau G.A.
        Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes.
        Nat Commun. 2019; 10: 4450

      Linked Article