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Families, Health Registers, and Biobanks: Making the Unmeasurable Measurable

  • Clara Climent Albiñana
    Affiliations
    National Centre for Register-based Research, Aarhus University, Aarhus, Denmark
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  • Bjarni J. Vilhjálmsson
    Affiliations
    National Centre for Register-based Research, Aarhus University, Aarhus, Denmark
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  • John J. McGrath
    Correspondence
    Address correspondence to John J. McGrath, M.D., Ph.D., Queensland Brain Institute, QBI Building, 79, University of Queensland, St. Lucia, Queensland 4072, Australia.
    Affiliations
    National Centre for Register-based Research, Aarhus University, Aarhus, Denmark

    Queensland Brain Institute, University of Queensland, St. Lucia, Australia

    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Queensland, Australia
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      Linked Article

      • Inherited Risk for Autism Through Maternal and Paternal Lineage
        Biological PsychiatryVol. 88Issue 6
        • Preview
          Autism spectrum disorder (ASD) is highly familial, with a positively skewed male-to-female ratio that is purported to arise from the so-called female protective effect. A serious implication of a female protective effect is that familial ASD liability would be expected to aggregate asymptomatically in sisters of affected probands, who would incur elevated rates of ASD among their offspring. Currently, there exist no data on second-generation recurrence rates among families affected by ASD.
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