The Impact of Attention-Deficit/Hyperactivity Disorder Medications on Suicidality: Implications and Mechanisms

  • Stephen V. Faraone
    Address correspondence to Stephen V. Faraone, Ph.D., Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210.
    Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, New York
    Search for articles by this author
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Cortese S.
        • Adamo N.
        • Del Giovane C.
        • Mohr-Jensen C.
        • Hayes A.J.
        • Carucci S.
        • et al.
        Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: A systematic review and network meta-analysis.
        Lancet Psychiatry. 2018; 5: 727-738
        • Mueller A.K.
        • Fuermaier A.B.
        • Koerts J.
        • Tucha L.
        Stigma in attention deficit hyperactivity disorder.
        Atten Defic Hyperact Disord. 2012; 4: 101-114
        • Chang Z.
        • Quinn P.D.
        • O’Reilly L.
        • Sjölander A.
        • Hur K.
        • Gibbons R.
        • et al.
        Medication for attention-deficit/hyperactivity disorder and risk for suicide attempts.
        Biol Psychiatry. 2020; 88: 452-458
        • Septier M.
        • Stordeur C.
        • Zhang J.
        • Delorme R.
        • Cortese S.
        Association between suicidal spectrum behaviors and attention-deficit/hyperactivity disorder: A systematic review and meta-analysis.
        Neurosci Biobehav Rev. 2019; 103: 109-118
        • Carpiniello B.
        • Pinna F.
        The reciprocal relationship between suicidality and stigma.
        Front Psychiatry. 2017; 8: 35
        • Huang K.L.
        • Wei H.T.
        • Hsu J.W.
        • Bai Y.M.
        • Su T.P.
        • Li C.T.
        • et al.
        Risk of suicide attempts in adolescents and young adults with attention-deficit hyperactivity disorder: A nationwide longitudinal study.
        Br J Psychiatry. 2018; 212: 234-238
        • Liang S.H.
        • Yang Y.H.
        • Kuo T.Y.
        • Liao Y.T.
        • Lin T.C.
        • Lee Y.
        • et al.
        Suicide risk reduction in youths with attention-deficit/hyperactivity disorder prescribed methylphenidate: A Taiwan nationwide population-based cohort study.
        Res Dev Disabil. 2018; 72: 96-105
        • Chen Q.
        • Sjölander A.
        • Runeson B.
        • D’Onofrio B.M.
        • Lichtenstein P.
        • Larsson H.
        Drug treatment for attention-deficit/hyperactivity disorder and suicidal behaviour: Register based study.
        BMJ. 2014; 348: g3769
        • Biederman J.
        • DiSalvo M.
        • Fried R.
        • Woodworth K.Y.
        • Biederman I.
        • Faraone S.V.
        Quantifying the protective effects of stimulants on functional outcomes in attention-deficit/hyperactivity disorder: A focus on number needed to treat statistic and sex effects.
        J Adolesc Health. 2019; 65: 784-789
        • Boland H.
        • DiSalvo M.
        • Fried R.
        • Woodworth K.Y.
        • Wilens T.
        • Faraone S.V.
        • et al.
        A literature review and meta-analysis on the effects of ADHD medications on functional outcomes.
        J Psychiatr Res. 2020; 123: 21-30

      Linked Article