A Mechanistic Study of p11 Reveals a Promising New Rapid-Action Antidepressant Target

  • Bradley R. Miller
    Address correspondence to Bradley R. Miller, M.D., Ph.D., Department of Psychiatry, Columbia University, Kolb Annex, 40 Haven Ave, Rm 759, Unit 87, New York, NY 10032.
    Division of Systems Neuroscience, Department of Psychiatry, Columbia University, New York, New York
    Research Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, New York
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        • World Health Organization
        Depression and other common mental disorders: Global health estimates..
        (Available at:)
        Date: 2017
        Date accessed: November 21, 2018
        • Medrihan L.
        • Umschweif G.
        • Sinha A.
        • Reed S.
        • Lee J.
        • Gindinova K.
        • et al.
        Reduced Kv3.1 activity in dentate gyrus parvalbumin cells induces vulnerability to depression.
        Biol Psychiatry. 2020; 88: 405-414
        • Pereira V.S.
        • Hiroaki-Sato V.A.
        A brief history of antidepressant drug development: From tricyclics to beyond ketamine.
        Acta Neuropsychiatr. 2018; 30: 307-322
        • Wei Y.
        • Chang L.
        • Hashimoto K.
        A historical review of antidepressant effects of ketamine and its enantiomers.
        Pharmacol Biochem Behav. 2020; 190: 172870
        • Gordon J.A.
        From neurobiology to novel medications: A principled approach to translation.
        Am J Psychiatry. 2019; 176: 425-427
        • Svenningsson P.
        • Chergui K.
        • Rachleff I.
        • Flajolet M.
        • Zhang X.
        • El Yacoubi M.
        • et al.
        Alterations in 5-HT1B receptor function by p11 in depression-like states.
        Science. 2006; 311: 77-80
        • Seo J.S.
        • Svenningsson P.
        Modulation of ion channels and receptors by p11 (S100A10).
        Trends Pharmacol Sci. 2020; 41: 487-497
        • Umschweif G.
        • Greengard P.
        • Sagi Y.
        The dentate gyrus in depression [published online ahead of print Dec 7].
        Eur J Neurosci. 2019;
        • Taskin B.
        • von Schoubye N.L.
        • Sheykhzade M.
        • Bastlund J.F.
        • Grunnet M.
        • Jespersen T.
        Biophysical characterization of KV3.1 potassium channel activating compounds.
        Eur J Pharmacol. 2015; 758: 164-170
        • Anacker C.
        • Luna V.M.
        • Stevens G.S.
        • Millette A.
        • Shores R.
        • Jimenez J.C.
        • et al.
        Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.
        Nature. 2018; 559: 98-102

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