Recently, Ousdal et al. (
1
) reported widespread changes in cortical and subcortical volumes after electroconvulsive
therapy (ECT). They reported that although the number of ECT sessions is associated
with changes in multiple volumes in the brain, clinical response is not. While their
analyses are sound and open up new research avenues, and their dataset is adequately
powered, an important question remains.To read this article in full you will need to make a payment
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References
- Brain changes induced by electroconvulsive therapy are broadly distributed.Biol Psychiatry. 2020; 87: 451-461
- Volume increase in the dentate gyrus after electroconvulsive therapy in depressed patients as measured with 7T.Mol Psychiatry. 2020; 25: 1559-1568
- Repeated measures correlation.Front Psychol. 2017; 8: 456
- Volume increase of the dentate gyrus induced by electroconvulsive therapy.J ECT. 2019; 35: e57-e58
- Acute and long-term effects of electroconvulsive therapy on human dentate gyrus.Neuropsychopharmacology. 2019; 44: 1805-1811
- Immediate and long-term effects of bilateral electroconvulsive therapy on cognitive functioning in patients with a depressive disorder.J Affect Disord. 2018; 238: 659-665
- The dentate gyrus in depression: Directions for future research [published online ahead of print Feb 17; correction published Apr 22].Mol Psychiatry. 2020;
Article info
Publication history
Published online: August 04, 2020
Accepted:
May 27,
2020
Received:
March 23,
2020
Footnotes
See also associated correspondence: https://doi.org/10.1016/j.biopsych.2020.05.031.
Identification
Copyright
© 2020 Society of Biological Psychiatry.
ScienceDirect
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- Brain Changes Induced by Electroconvulsive Therapy Are Broadly DistributedBiological PsychiatryVol. 87Issue 5
- PreviewElectroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response.
- Full-Text
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- Reply to: Clinical Relevance of Brain Changes After Electroconvulsive Therapy: Is There Really No Link at All?Biological PsychiatryVol. 89Issue 4
- PreviewIn our recent publication (1), we reported widespread gray matter volumetric increases following electroconvulsive therapy (ECT) in a sample of 328 depressed patients from 14 independent sites. The volumetric increases encompassed 79 of 84 cortical and subcortical gray matter regions of interest (ROIs), including the hippocampus, and were paralleled by a significant decrease in total ventricle volume. However, the volumetric changes of the gray matter ROIs were not significantly associated with changes in depression scores in a general linear model (GLM).
- Full-Text
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