Decomposing Heterogeneity in Autism Spectrum Disorder Through Neurosubtyping

  • So Hyun Kim
    Address correspondence to So Hyun Kim, Ph.D., Center for Autism and the Developing Brain, Department of Psychiatry, Weill Cornell Medicine, 21 Bloomingdale Rd, White Plains, NY 10605.
    Center for Autism and the Developing Brain, Department of Psychiatry, Weill Cornell Medicine, White Plains, New York
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        • Kapur S.
        • Phillips A.G.
        • Insel T.R.
        Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?.
        Mol Psychiatry. 2012; 17: 1174-1179
        • Kim S.H.
        • Bal V.H.
        • Benrey N.
        • Choi Y.B.
        • Guthrie W.
        • Colombi C.
        • Lord C.
        Variability in autism symptom trajectories using repeated observations from 14 to 36 months of age.
        J Am Acad Child Adolesc Psychiatry. 2018; 57: 837-848.e2
        • Lord C.
        • Brugha T.S.
        • Charman T.
        • Cusack J.
        • Dumas G.
        • Frazier T.
        • et al.
        Autism spectrum disorder.
        Nat Rev Dis Primers. 2020; 6: 5
        • Lombardo M.V.
        • Lai M.C.
        • Baron-Cohen S.
        Big data approaches to decomposing heterogeneity across the autism spectrum.
        Mol Psychiatry. 2019; 24: 1435-1450
      1. S.-J. Hong, J.T. Vogelstein, A. Gozzi, B.C. Bernhardt, B.T.T. Yeo, M.P. Milham, A. Di Martino (in press): Toward neurosubtypes in autism. Biol Psychiatry.

        • Chen H.
        • Uddin L.Q.
        • Guo X.
        • Wang J.
        • Wang R.
        • Wang X.
        • et al.
        Parsing brain structural heterogeneity in males with autism spectrum disorder reveals distinct clinical subtypes.
        Hum Brain Mapp. 2019; 40: 628-637
        • Duffy F.H.
        • Als H.
        Autism, spectrum or clusters? An EEG coherence study.
        BMC Neurol. 2019; 19: 27
        • Tang S.
        • Sun N.
        • Floris D.L.
        • Zhang X.
        • Di Martino A.
        • Yeo B.T.T.
        Reconciling dimensional and categorical models of autism heterogeneity: A brain connectomics and behavioral study.
        Biol Psychiatry. 2020; 87: 1071-1082
        • Georgiades S.
        • Bishop S.L.
        • Frazier T.
        Editorial perspective: Longitudinal research in autism - introducing the concept of ‘chronogeneity.’.
        J Child Psychol Psychiatry. 2017; 58: 634-636
        • Jeste S.S.
        • Geschwind D.H.
        Disentangling the heterogeneity of autism spectrum disorder through genetic findings.
        Nat Rev Neurol. 2014; 10: 74-81

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