Cortical Regulation of the Ability to Resist Temptation for Punishment-Paired Alcohol

  • F. Woodward Hopf
    Address correspondence to F. Woodward Hopf, Ph.D., Department of Psychiatry, Indiana University School of Medicine, 320 West 15th Street, NB 300E, Indianapolis, IN 46202.
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana
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      Linked Article

      • Prefrontal Regulation of Punished Ethanol Self-administration
        Biological PsychiatryVol. 87Issue 11
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          A clinical hallmark of alcohol use disorder is persistent drinking despite potential adverse consequences. The ventromedial prefrontal cortex (vmPFC) and dorsomedial prefrontal cortex (dmPFC) are positioned to exert top-down control over subcortical regions, such as the nucleus accumbens shell (NAcS) and basolateral amygdala, which encode positive and negative valence of ethanol (EtOH)-related stimuli. Prior rodent studies have implicated these regions in regulation of punished EtOH self-administration (EtOH-SA).
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