Alterations in Measures of Neuroplasticity Following Sleep Deprivation and Recovery Sleep in Major Depression

      50% of individuals with major depressive disorder (MDD) show rapid mood improvement following sleep deprivation, yet relapse once sleep occurs. This pattern may be due to changes in neuroplasticity as BDNF, a key component regulating neuroplasticity, is reduced in MDD and increases with sleep deprivation. The current objective was to examine changes in neuroplasticity during sleep deprivation and recovery sleep using serum BDNF and behavioral measures of learning and memory.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect