Abstract
Background
To achieve goals, organisms are often faced with complex tasks that require enhanced
control of cognitive faculties for optimal performance. However, the neural circuit
mechanisms underlying this ability are unclear. The claustrum is proposed to mediate
a variety of functions ranging from sensory binding to cognitive control of action,
but direct functional assessments of this telencephalic nucleus are lacking.
Methods
Here, we employed the Gnb4 (guanine nucleotide-binding subunit beta-4) cre driver line in mice to selectively
monitor and manipulate claustrum projection neurons during 1-choice versus 5-choice
serial reaction time task performance.
Results
Using fiber photometry, we found elevated claustrum activity prior to an expected
cue during correct performance on the cognitively demanding 5-choice response assay
relative to the less demanding 1-choice version of the task. Claustrum activity during
reward acquisition was also enhanced when task demand was higher. Furthermore, optogenetically
inhibiting the claustrum prior to the onset of the cue reduced choice accuracy on
the 5-choice task but not on the 1-choice task.
Conclusions
These results suggest that the claustrum supports a cognitive control function necessary
for optimal behavioral performance under cognitively demanding conditions.
Keywords
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Article info
Publication history
Published online: April 10, 2020
Accepted:
March 28,
2020
Received in revised form:
March 10,
2020
Received:
November 5,
2019
Identification
Copyright
© 2020 Society of Biological Psychiatry.
