In this review, Birnie et al. (pages 875–884) focus on the impacts of early-life adversity on the reward circuit and its functions.
The authors discuss how to compare reward circuit development in humans and rodents
and suggest that pathways defined by the expression of stress-sensitive molecules
including corticotropin-releasing factor might be particularly vulnerable to the disruptive
effects of early-life stress/adversity on the maturation of a functional reward circuit.
These approaches provide valuable insights into the novel mechanisms by which the
disruptive effects of early-life adversity may contribute to the development of aberrant
behaviors and mental illness, including anhedonia, drug-seeking, depression, and schizophrenia.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Biological PsychiatryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
