In This Issue| Volume 87, ISSUE 10, P867, May 15, 2020

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In This Issue

        In this review, Birnie et al. (pages 875–884) focus on the impacts of early-life adversity on the reward circuit and its functions. The authors discuss how to compare reward circuit development in humans and rodents and suggest that pathways defined by the expression of stress-sensitive molecules including corticotropin-releasing factor might be particularly vulnerable to the disruptive effects of early-life stress/adversity on the maturation of a functional reward circuit. These approaches provide valuable insights into the novel mechanisms by which the disruptive effects of early-life adversity may contribute to the development of aberrant behaviors and mental illness, including anhedonia, drug-seeking, depression, and schizophrenia.
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