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Altered Cognitive Control-Related Brain Activity and Functional Connectivity in First-Episode Schizophrenia & Clinical-High-Risk Youth

      Cognitive impairments are considered the core deficits in psychosis, and studies have revealed similar impairments in youth at clinical high-risk for psychosis (CHR). Dysfunction in the dorsolateral prefrontal cortex (DLPFC) is the consistently replicated region underlying such cognitive impairments across phases of psychotic illness. However, DLPFC-involved connectivity underlying cognitive impairments in the first episode psychosis (FEP) and CHR remains elusive.
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