Aggression is characteristic of multiple neuropsychiatric disorders and can have a
wide variety of negative effects on patients, their families, and the public. Recent
studies have implicated brain reward circuits in aggression and suggest that, in subsets
of aggressive individuals, repeated domination of subordinate social targets is reinforcing.
We show that orexin neurons originating from the lateral hypothalamus activate a population
of GABAergic interneurons in the lateral habenula (LHb) via orexin receptor 2 to promote
aggression and aggression reward.
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© 2020 Published by Elsevier Inc.
