Orexin Inputs to GABAergic Lateral Habenula Neurons Control the Valence of Aggression

      Aggression is characteristic of multiple neuropsychiatric disorders and can have a wide variety of negative effects on patients, their families, and the public. Recent studies have implicated brain reward circuits in aggression and suggest that, in subsets of aggressive individuals, repeated domination of subordinate social targets is reinforcing. We show that orexin neurons originating from the lateral hypothalamus activate a population of GABAergic interneurons in the lateral habenula (LHb) via orexin receptor 2 to promote aggression and aggression reward.
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