There is growing evidence for inflammation as a risk factor for depression, and vice-versa.
However, the underlying question of whether one causes the other has not been tested
using naturally occurring fluctuations in inflammatory biomarkers or symptoms. This
study separates predictors into between-person and within-person components to gain
greater clarity about this relationship. Importantly, with this approach, within-person
variance components can test potential causal associations between variables while
controlling for differences in an individual’s average levels of a predictor.
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© 2020 Published by Elsevier Inc.
