Abstract| Volume 87, ISSUE 9, SUPPLEMENT , S47, May 01, 2020

Bidirectional Associations Between Inflammatory Biomarkers and Depression Symptoms in Adolescents: Potential Causal Relationships

      There is growing evidence for inflammation as a risk factor for depression, and vice-versa. However, the underlying question of whether one causes the other has not been tested using naturally occurring fluctuations in inflammatory biomarkers or symptoms. This study separates predictors into between-person and within-person components to gain greater clarity about this relationship. Importantly, with this approach, within-person variance components can test potential causal associations between variables while controlling for differences in an individual’s average levels of a predictor.
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