Cognitive symptoms of depression include the negative memory bias. The hippocampus
could contribute to this cognitive symptom. The susceptibility of depression symptoms
is related to enhanced hippocampal function. Activating hippocampal extrasynaptic
NMDA receptors, which is related to forgetting, could facilitate the resilience to
chronic stress, a risk factor of depression. We reasoned that hippocampal engrams,
which are neural substrates for memory, could underlie some hippocampal contributions
to depression.
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© 2020 Published by Elsevier Inc.
