Cognitive symptoms of depression include the negative memory bias. The hippocampus could contribute to this cognitive symptom. The susceptibility of depression symptoms is related to enhanced hippocampal function. Activating hippocampal extrasynaptic NMDA receptors, which is related to forgetting, could facilitate the resilience to chronic stress, a risk factor of depression. We reasoned that hippocampal engrams, which are neural substrates for memory, could underlie some hippocampal contributions to depression.
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