Twin studies have demonstrated a shared genetic architecture across disorders and
traits characterized by behavioral disinhibition. The underlying latent factor has
been called Externalizing and is highly heritable (∼80%). Externalizing is a core
feature of many psychiatric and substance use disorders. We have launched a consortium
that is performing multivariate genome-wide association studies (GWAS) of externalizing
phenotypes.
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© 2020 Published by Elsevier Inc.
