Abstract| Volume 87, ISSUE 9, SUPPLEMENT , S27-S28, May 01, 2020

Studying Underlying Risk Dimensions to Aid in Gene identification: Findings From the Externalizing Consortium

      Twin studies have demonstrated a shared genetic architecture across disorders and traits characterized by behavioral disinhibition. The underlying latent factor has been called Externalizing and is highly heritable (∼80%). Externalizing is a core feature of many psychiatric and substance use disorders. We have launched a consortium that is performing multivariate genome-wide association studies (GWAS) of externalizing phenotypes.
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