SYMPOSIUM| Volume 87, ISSUE 9, SUPPLEMENT , S25, May 01, 2020

Single-Nucleus Transcriptomic Analysis of PTSD and MDD in Human Post-Mortem DLPFC

      Many advances have been made towards understanding the biophysical and genetic architecture of stress-related psychiatric disorders such as PTSD and MDD. However, less work has focused on identifying how particular neuronal cell types contribute to observed molecular alterations. Perturbations in dorsal lateral prefrontal cortex (DLPFC) function and connectivity have been widely implicated in the development of both MDD and PTSD. Thus, we undertook a single-nucleus RNA-sequencing (snRNAseq) study of the dlPFC in human post-mortem brain tissue to identify cell-type specific transcriptional changes associated with PTSD and/or MDD.
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