Many advances have been made towards understanding the biophysical and genetic architecture
of stress-related psychiatric disorders such as PTSD and MDD. However, less work has
focused on identifying how particular neuronal cell types contribute to observed molecular
alterations. Perturbations in dorsal lateral prefrontal cortex (DLPFC) function and
connectivity have been widely implicated in the development of both MDD and PTSD.
Thus, we undertook a single-nucleus RNA-sequencing (snRNAseq) study of the dlPFC in
human post-mortem brain tissue to identify cell-type specific transcriptional changes
associated with PTSD and/or MDD.
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© 2020 Published by Elsevier Inc.
