Anorexia Nervosa (AN) is characterized by persistent dietary restriction that leads
to starvation. Disturbed eating patterns are associated with poor long-term outcomes,
including a high mortality rate. Yet, the neural mechanisms that guide extreme, pathological
restrictive eating are unclear. We have shown that a computer-based Food Choice Task,
which directly probes food-based decisions during functional MRI, captures the restrictive
eating seen among individuals with AN, and is associated with actual caloric intake.
Across two studies, we have shown that active decision-making about food among AN,
relative to HC, was related to engagement of the dorsal striatum. This approach also
offers an opportunity to examine variability in eating patterns.
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© 2020 Published by Elsevier Inc.
