Neural and Behavioral Mechanisms of Food Decision Making Across a Spectrum of Restrictive Eating

      Anorexia Nervosa (AN) is characterized by persistent dietary restriction that leads to starvation. Disturbed eating patterns are associated with poor long-term outcomes, including a high mortality rate. Yet, the neural mechanisms that guide extreme, pathological restrictive eating are unclear. We have shown that a computer-based Food Choice Task, which directly probes food-based decisions during functional MRI, captures the restrictive eating seen among individuals with AN, and is associated with actual caloric intake. Across two studies, we have shown that active decision-making about food among AN, relative to HC, was related to engagement of the dorsal striatum. This approach also offers an opportunity to examine variability in eating patterns.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect