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The Association Between Medication, Dopamine Function, and Long-Term Symptom Severity in the Matured and Developing Brain in ADHD

      We previously demonstrated in a randomized clinical trial (RCT) that methylphenidate (MPH) treatment in boys, but not men, with attention-deficit/ hyperactivity disorder (ADHD) alters dopamine function 1 week after RCT end. However, changes in dopamine function did not correlate with clinical outcome. Here, we assess whether clinical outcome at longitudinal follow-up is predicted by baseline dopamine function and whether clinical outcome is modulated by medication.
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