Studies suggest that microglia activation may be a potential biomarker of depression.
However, there are also contradictory data suggesting microglia activation is not
altered in patients with major depressive disorder. Inconsistencies may stem from
sex differences in microglia, their activation status and activation purpose. We will
present data demonstrating specific sex differences in microglia activation in response
to stress in a preclinical model. These sex differences have functional implications
as response to a classical activation inhibitor is sex-specific.
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© 2020 Published by Elsevier Inc.
