Preclinical and clinical studies suggest that inflammation and vascular dysfunction
contributes to the pathogenesis of major depressive disorder. Chronic social stress
alters blood-brain barrier (BBB) integrity through loss of tight junction protein
claudin-5 (cldn5) in male mice, promoting passage of circulating proinflammatory cytokines
and depression-like behaviors. This effect is prominent within the nucleus accumbens
(NAc), a brain region associated with mood regulation, however the mechanisms involved
are unclear. Moreover, compensatory responses leading to proper behavioral strategies
and active resilience are unknown.
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© 2020 Published by Elsevier Inc.
