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Social Stress Induces Blood-Brain Barrier Leakiness and Molecular Alterations Promoting Depression or Stress Resilience

      Preclinical and clinical studies suggest that inflammation and vascular dysfunction contributes to the pathogenesis of major depressive disorder. Chronic social stress alters blood-brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting passage of circulating proinflammatory cytokines and depression-like behaviors. This effect is prominent within the nucleus accumbens (NAc), a brain region associated with mood regulation, however the mechanisms involved are unclear. Moreover, compensatory responses leading to proper behavioral strategies and active resilience are unknown.
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