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Neurocognitive Subtypes in Bipolar Disorder: Clinical and Biological Correlates

      Recent data suggest cognitive impairments in many patients with bipolar disorder (BD) that contribute directly to functional disability; however, substantial cognitive heterogeneity exists. Using empirical approaches to classify individuals along cognitive dimensions into more homogenous subgroups, we previously reported three resultant cognitive subgroups with differential profiles that are relatively equally distributed as 1) cognitively-intact; 2) selectively-impaired; and 3) globally-impaired. These subgroups do not simply recapitulate existing clinical subtypes (e.g. BD I vs II; psychotic subtype) but represent a novel classification.
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