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Neurobiological and Functional Trajectories in Distinct Cognitive Subtypes: Predicting Neuroprogression in First Episode Psychosis

      Progressive changes in neurobiology and cognition have been reported following psychosis onset; however, findings have been inconsistent, perhaps due in part to heterogeneity in cognitive, neurobiological, and clinical presentations commonly observed in psychosis. Abnormalities in brain structure and connectivity are associated with distinct cognitive subtypes cross-sectionally. Here we leverage this heterogeneity to characterize neuroprogressive trajectories over the first year of illness in patients with psychosis.
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