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Paraventricular Thalamic Regulation of Habituation to Repeated Stress

      Habituation is the progressive decline in responses to repeated exposure to predictable, moderately intense stressors. Learning and memory underlie the ability to habituate and these are disrupted in disorders such as PTSD. We previously identified the posterior paraventricular thalamic nucleus (pPVT) as crucial in regulating habituation. Here, we investigated the activity-regulated cytoskeleton-associated protein (Arc), an immediate early gene that promotes synaptic and structural plasticity underlying learning and memory, in the regulation of habituation.
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