Habituation is the progressive decline in responses to repeated exposure to predictable,
moderately intense stressors. Learning and memory underlie the ability to habituate
and these are disrupted in disorders such as PTSD. We previously identified the posterior
paraventricular thalamic nucleus (pPVT) as crucial in regulating habituation. Here,
we investigated the activity-regulated cytoskeleton-associated protein (Arc), an immediate
early gene that promotes synaptic and structural plasticity underlying learning and
memory, in the regulation of habituation.
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© 2020 Published by Elsevier Inc.
