Sub-Thalamic Modulation of Fear

      Pathological fear generalization is a central feature of trauma- and anxiety- related disorders. The sub-thalamic zona incerta (ZI), typically considered a sensorimotor relay, has recently gained attention for its role in modulating emotional states. We previously identified that activation of the GABAergic cells in the mouse ZI, can prevent fear generalization. Here, we examined whether specific inhibitory projections from the ZI could mediate changes in fear generalization.
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