First onsets of depression are especially common in adolescent females and often develop into chronic/recurrent illness. Our understanding of the multiple etiological processes leading to first onset, and particularly with a chronic/recurrent course, remains limited. We examined whether a comprehensive panel of clinical, cognitive-dispositional, interpersonal, and biological (cortisol, event-related potentials) risk factors prospectively predicts first onset of depressive disorder (DD) and of DD with a chronic/recurrent course over 3 years in adolescent girls.
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