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Modeling Reward-Circuit Function to Predict Development of Adolescent Depression and Anhedonia

      Disrupted function in neural reward circuitry characterizes depression and has prognostic value for worsening of symptoms and depression onset. Examining the role of reward circuitry is particularly important during adolescence, a period marked by ongoing development in reward circuitry, changes in reward-driven behavior, and the onset of affective disorders. Reward-circuit function is postulated to underlie anhedonia, the difficulty with reward motivation or experience that emerges during adolescence and occurs across several forms of psychopathology. We used sophisticated computational approaches to investigate the value of reward-circuit function for predicting adolescent anhedonia.
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