Twin studies identify age-related changes in genetic influences on depression, suggesting
that genetic vulnerability to depression may operate differently across development.
However, current psychiatric polygenic risk scores (PRS) have been derived in cross-sectional
studies in adults. The aim of the current study was to test whether the polygenic
risk score prediction generalizes to depression in a community sample of youth, and
to examine the interplay between PRSs and developmental trajectories of depression.
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