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Developmental Changes in Polygenetic Risk Score Prediction of Depression in Community Youth

      Twin studies identify age-related changes in genetic influences on depression, suggesting that genetic vulnerability to depression may operate differently across development. However, current psychiatric polygenic risk scores (PRS) have been derived in cross-sectional studies in adults. The aim of the current study was to test whether the polygenic risk score prediction generalizes to depression in a community sample of youth, and to examine the interplay between PRSs and developmental trajectories of depression.
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