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Absence of Default Mode Downregulation in Response to a Mild Psychological Stressor Marks Stress-Vulnerability Across Diverse Psychiatric Disorders

      Vulnerability to stress is a common feature across a broad spectrum of psychiatric disorders, but this link has been mechanistically studied almost exclusively in patients with so-called stress-related disorders such as depression and anxiety. To probe transdiagnostic mechanisms, we set out to study the acute stress response across a broader range of psychiatric disorders taking a large-scale brain network perspective.
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