Individual Differences in Immune-Brain Interface Promotes Stress Vulnerability: Implications for the Study of Depression

      Studies suggest that heightened inflammation contributes to major depressive disorder (MDD) pathogenesis. Using chronic social defeat stress (CSDS)—a mouse model for the study of individual differences in depression sensitivity—we found breakdown of the endothelial barrier leading to interleukin 6 infiltration and to increased stress susceptibility. However, there is a limited understanding of the mechanisms promoting immune infiltration.
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