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Ancestral Effects of Maltreatment: Epigenetic Consequences in Rhesus Monkeys

      Exposure to early life stress can significantly contribute to the pathophysiology of psychiatric disorders in adulthood. Environmental stress in antecedent generations may additionally influence the risk to develop psychiatric disorders in offspring, leading to a vicious cycle of disease risk. Here we present data on a model of early life stress in non-human primates investigating the biological transmission of stress from the parental generation to the offspring and its functional epigenetic implications in the offspring on the level of DNA methylation changes in stress-related genes and on the genome-wide level.
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