Exposure to early life stress can significantly contribute to the pathophysiology
of psychiatric disorders in adulthood. Environmental stress in antecedent generations
may additionally influence the risk to develop psychiatric disorders in offspring,
leading to a vicious cycle of disease risk. Here we present data on a model of early
life stress in non-human primates investigating the biological transmission of stress
from the parental generation to the offspring and its functional epigenetic implications
in the offspring on the level of DNA methylation changes in stress-related genes and
on the genome-wide level.
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© 2020 Published by Elsevier Inc.
