Commentary| Volume 87, ISSUE 7, P590-591, April 01, 2020

Advancing Alcohol Genetics Research: One Genome-wide Association Study at a Time and Beyond

  • Janitza L. Montalvo-Ortiz
    Address correspondence to Janitza L. Montalvo-Ortiz, Ph.D., Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue 116A2, West Haven, CT 06516.
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, and the Veterans Affairs Connecticut Healthcare Center, West Haven, Connecticut
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      Linked Article

      • Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse
        Biological PsychiatryVol. 87Issue 7
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          Alcohol use disorder (AUD) is defined by several symptom criteria, which can be dissected further at the genetic level. Over the past several years, our understanding of the genetic factors influencing alcohol use and abuse has progressed tremendously; numerous loci have been implicated in different aspects of alcohol use. Previously known associations with alcohol-metabolizing enzymes (ADH1B, ALDH2) have been replicated definitively. In addition, novel associations with loci containing the genes KLB, GCKR, CRHR1, and CADM2 have been reported.
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