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Article info
Publication history
Accepted:
November 26,
2019
Received in revised form:
November 25,
2019
Received:
November 22,
2019
Identification
Copyright
© 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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- Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine TrialBiological PsychiatryVol. 87Issue 6
- PreviewPosttraumatic stress disorder, an area of large unmet medical needs, is characterized by persistence of fear memories and maladaptive stress responses. In rodents, elevation of the endocannabinoid anandamide due to inhibition of fatty acid amide hydrolase (FAAH) facilitates fear extinction and protects against the anxiogenic effects of stress. We recently reported that elevated anandamide levels in people homozygous for a loss-of-function FAAH mutation are associated with a similar phenotype, suggesting a translational validity of the preclinical findings.
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