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Effects of Maternal Prenatal Stress on the Fetal Brain and Hope for the Prevention of Psychopathology

  • Vivette Glover
    Correspondence
    Address correspondence to Vivette Glover, Ph.D., Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 ONN, United Kingdom.
    Affiliations
    Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
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      Linked Article

      • Maternal Prenatal Stress Is Associated With Altered Uncinate Fasciculus Microstructure in Premature Neonates
        Biological PsychiatryVol. 87Issue 6
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          Maternal prenatal stress exposure (PNSE) increases risk for adverse psychiatric and behavioral outcomes in offspring. The biological basis for this elevated risk is poorly understood but may involve alterations to the neurodevelopmental trajectory of white matter tracts within the limbic system, particularly the uncinate fasciculus. Additionally, preterm birth is associated with both impaired white matter development and adverse developmental outcomes. In this study we hypothesized that higher maternal PNSE was associated with altered uncinate fasciculus microstructure in offspring.
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