Looking at the Big Neurochemical Picture of Autism Spectrum Disorder

  • Natalia Jaworska
    Address correspondence to Natalia Jaworska, Ph.D., Clinical EEG & Neuroimaging Laboratory, Royal’s Institute of Mental Health Research, Room 3129, 1145 Carling Ave, Ottawa ON K1Z7K4, Canada.
    The Royal’s Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Brain and Mind Research Institute, University of Ottawa, Ottawa, Ontario, Canada
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      Linked Article

      • Parsing the Heterogeneity of Brain Metabolic Disturbances in Autism Spectrum Disorder
        Biological PsychiatryVol. 87Issue 2
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          Despite rising prevalence of autism spectrum disorder (ASD), its brain bases remain uncertain. Abnormal levels of N-acetyl compounds, glutamate+glutamine, creatine+phosphocreatine, or choline compounds measured by proton magnetic resonance spectroscopy suggest that neuron or glial density, mitochondrial energetic metabolism, and/or inflammation contribute to ASD neuropathology. The neuroanatomic distribution of these metabolites could help evaluate leading theories of ASD. However, most prior magnetic resonance spectroscopy studies had small samples (all <60, most <20), interrogated only a small fraction of the brain, and avoided assessing effects of age, sex, and IQ.
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