Early Career Investigator Commentary| Volume 86, ISSUE 12, e47-e48, December 15, 2019

The Uncinate Fasciculus in Anxiety Disorders: A Potential Treatment Target?

  • Julia O. Linke
    Address correspondence to Julia O. Linke, Ph.D., Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, MSC-2670, Building 15K, Bethesda, MD 20892-2670.
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
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      Linked Article

      • The Relationship Between the Uncinate Fasciculus and Anxious Temperament Is Evolutionarily Conserved and Sexually Dimorphic
        Biological PsychiatryVol. 86Issue 12
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          Anxious temperament (AT) is an early-life heritable trait that predisposes individuals to develop anxiety and depressive disorders. Our previous work in preadolescent children suggests alterations in the uncinate fasciculus (UF), the white matter tract that connects prefrontal with limbic regions, in boys with anxiety disorders. Here, using a nonhuman primate model of AT, we tested whether this sexually dimorphic finding is evolutionarily conserved and examined the extent to which heritable and environmental influences contribute to UF microstructure.
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