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The Uncinate Fasciculus in Anxiety Disorders: A Potential Treatment Target?

  • Julia O. Linke
    Correspondence
    Address correspondence to Julia O. Linke, Ph.D., Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, MSC-2670, Building 15K, Bethesda, MD 20892-2670.
    Affiliations
    Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
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      References

        • Sampaio-Baptista C.
        • Johansen-Berg H.
        White matter plasticity in the adult brain.
        Neuron. 2017; 96: 1239-1251
        • Tromp D.P.M.
        • Fox A.S.
        • Oler J.A.
        • Alexander A.L.
        • Kalin N.H.
        The relationship between the uncinate fasciculus and anxious temperament is evolutionarily conserved and sexually dimorphic.
        Biol Psychiatry. 2019; 86: 890-898
        • Tromp D.P.M.
        • Williams L.E.
        • Fox A.S.
        • Oler J.A.
        • Roseboom P.H.
        • Rogers G.M.
        • et al.
        Altered uncinate fasciculus microstructure in childhood anxiety disorders in boys but not girls.
        Am J Psychiatry. 2019; 176: 208-216
        • Basser P.J.
        • Pierpaoli C.
        Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI.
        J Magn Reson B. 1996; 111: 209-219
        • Beesdo K.
        • Knappe S.
        • Pine D.S.
        Anxiety and anxiety disorders in children and adolescents: Developmental issues and implications for DSM-V.
        Psychiatr Clin North Am. 2009; 32: 483-524
        • Beesdo K.
        • Lau J.Y.
        • Guyer A.E.
        • McClure-Tone E.B.
        • Monk C.S.
        • Nelson E.E.
        • et al.
        Common and distinct amygdala-function perturbations in depressed vs anxious adolescents.
        Arch Gen Psychiatry. 2009; 66: 275-285
        • Kircanski K.
        • White L.K.
        • Tseng W.L.
        • Wiggins J.L.
        • Frank H.R.
        • Sequeira S.
        • et al.
        A latent variable approach to differentiating neural mechanisms of irritability and anxiety in youth.
        JAMA Psychiatry. 2018; 75: 631-639
        • Pines A.R.
        • Sacchet M.D.
        • Kullar M.
        • Ma J.
        • Williams L.M.
        Multi-unit relations among neural, self-report, and behavioral correlates of emotion regulation in comorbid depression and obesity.
        Sci Rep. 2018; 8: 14032
        • Craske M.G.
        • Treanor M.
        • Conway C.C.
        • Zbozinek T.
        • Vervliet B.
        Maximizing exposure therapy: An inhibitory learning approach.
        Behav Res Ther. 2014; 58: 10-23
        • Lebel C.
        • Beaulieu C.
        Longitudinal development of human brain wiring continues from childhood into adulthood.
        J Neurosci. 2011; 31: 10937-10947

      Linked Article

      • The Relationship Between the Uncinate Fasciculus and Anxious Temperament Is Evolutionarily Conserved and Sexually Dimorphic
        Biological PsychiatryVol. 86Issue 12
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          Anxious temperament (AT) is an early-life heritable trait that predisposes individuals to develop anxiety and depressive disorders. Our previous work in preadolescent children suggests alterations in the uncinate fasciculus (UF), the white matter tract that connects prefrontal with limbic regions, in boys with anxiety disorders. Here, using a nonhuman primate model of AT, we tested whether this sexually dimorphic finding is evolutionarily conserved and examined the extent to which heritable and environmental influences contribute to UF microstructure.
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