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Population-Based Mapping of Polygenic Risk for Schizophrenia on the Human Brain: New Opportunities to Capture the Dimensional Aspects of Severe Mental Disorders

  • Lars T. Westlye
    Affiliations
    Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway

    Department of Psychology, University of Oslo, Oslo, Norway
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  • Dag Alnæs
    Affiliations
    Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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  • Dennis van der Meer
    Affiliations
    Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway

    School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
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  • Tobias Kaufmann
    Affiliations
    Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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  • Ole A. Andreassen
    Correspondence
    Address correspondence to Ole A. Andreassen, M.D., Ph.D., Norwegian Centre for Mental Disorders Research, Building 49, Oslo University Hospital, Ullevål, Kirkeveien 166, PO Box 4956 Nydalen, 0424 Oslo, Norway.
    Affiliations
    Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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      Linked Article

      • Impact of Polygenic Risk for Schizophrenia on Cortical Structure in UK Biobank
        Biological PsychiatryVol. 86Issue 7
        • Preview
          Schizophrenia is a neurodevelopmental disorder with many genetic variants of individually small effect contributing to phenotypic variation. Lower cortical thickness (CT), surface area, and cortical volume have been demonstrated in people with schizophrenia. Furthermore, a range of obstetric complications (e.g., lower birth weight) are consistently associated with an increased risk for schizophrenia. We investigated whether a high polygenic risk score for schizophrenia (PGRS-SCZ) is associated with CT, surface area, and cortical volume in UK Biobank, a population-based sample, and tested for interactions with birth weight.
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