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- Toward rational pharmacotherapy for posttraumatic stress disorder: An interim report.Am J Psychiatry. 1988; 145: 281-285
- Toward rational pharmacotherapy for posttraumatic stress disorder: Reprise.Am J Psychiatry. 2013; 170: 944-946
- Psychobiology and molecular genetics of resilience.Nat Rev Neurosci. 2009; 10: 446-457
- Understanding resilience and preventing and treating PTSD.Harv Rev Psychiatry. 2018; 26: 158-174
- Biomarkers for combat-related PTSD: Focus on molecular networks from high-dimensional data.Eur J Psychotraumatol. 2014; 5: 23938
- Neurobiology of resilience.Nat Neurosci. 2012; 15: 1475
- It is time to address the crisis in the pharmacotherapy of posttraumatic stress disorder: A consensus statement of the PTSD Psychopharmacology Working Group.Biol Psychiatry. 2017; 82: e51-e59
- Resilience definitions, theory, and challenges: Interdisciplinary perspectives.Eur J Psychotraumatol. 2014; 5: 25338
- Resilience processes in context: Contributions and implications of Bronfenbrenner's person-process-context model.J Aggress Maltreat Trauma. 2007; 14: 73-87
- VA/DOD Clinical Practice Guideline for the Management of Posttraumatic Stress Disorder and Acute Stress Disorder.Department of Veterans Affairs/Department of Defense, Washington, DC2017
ISTSS Guidelines Committee. Posttraumatic Stress Disorder Prevention and Treatment Guidelines: Methodology and Recommendations. Available at: http://www.istss.org/getattachment/Treating-Trauma/New-ISTSS-Prevention-and-Treatment-Guidelines/ISTSS_PreventionTreatmentGuidelines_FNL.pdf.aspx. Accessed December 23, 2018.
- Neural correlates of psychotherapeutic treatment of post-traumatic stress disorder: A systematic literature review.Front Psychiatry. 2017; 8: 85
- From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders.Neurobiol Learn Mem. 2014; 113: 3-18
- Reduced salience and enhanced central executive connectivity following PTSD treatment.Chronic Stress. 2019; 3 (2470547019838971)
- The meaning of evidence-based treatments for veterans with posttraumatic stress disorder.JAMA Psychiatry. 2016; 73: 433-434
- True evidence-based care for posttraumatic stress disorder in military personnel and veterans.JAMA Psychiatry. 2016; 73: 431-432
- Post-traumatic Stress Disorder.NICE, London2018
- Psychotherapy versus pharmacotherapy for posttraumatic stress disorder: Systemic review and meta-analyses to determine first-line treatments.Depress Anxiety. 2016; 33: 792-806
- Twenty-four hour urinary cortisol and catecholamine excretion in combat-related posttraumatic stress disorder.Biol Psychiatry. 1990; 27: 245-247
- Psychophysiologic assessment of posttraumatic stress disorder imagery in Vietnam combat veterans.Arch Gen Psychiatry. 1987; 44: 970-975
- Brain activation and heart rate during script-driven traumatic imagery in PTSD: Preliminary findings.Psychiatry Res Neuroimaging. 2012; 204: 155-160
- Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience.Brain Res. 2009; 1293: 13-23
- Abnormal noradrenergic function in posttraumatic stress disorder.Arch Gen Psychiatry. 1993; 50: 266-274
- Noradrenergic dysregulation in the pathophysiology of PTSD.Exp Neurol. 2016; 284: 181-195
- A placebo-controlled trial of guanfacine for the treatment of posttraumatic stress disorder in veterans.Psychopharmacol Bull. 2008; 41: 8-18
- No improvement of posttraumatic stress disorder symptoms with guanfacine treatment.Am J Psychiatry. 2006; 163: 2186-2188
- Targeting the noradrenergic system in posttraumatic stress disorder: A systematic review and meta-analysis of prazosin trials.Curr Drug Targets. 2015; 16: 1094-1106
- Efficacy of prazosin in posttraumatic stress disorder: A systematic review and meta-analysis.Prim Care Companion CNS Disord. 2016; 18: 16r01943
- Tracing the flow of knowledge: Geographic variability in the diffusion of prazosin use for the treatment of posttraumatic stress disorder nationally in the Department of Veterans Affairs.Arch Gen Psychiatry. 2009; 66: 417-421
- Trial of prazosin for post-traumatic stress disorder in military veterans.N Engl J Med. 2018; 378: 507-517
- Prevention of posttraumatic stress disorder with propranolol: A meta-analytic review.J Psychosom Res. 2015; 79: 89-93
- Systemic propranolol acts centrally to reduce conditioned fear in rats without impairing extinction.Biol Psychiatry. 2009; 65: 887-892
- Considering future pharmacotherapy for PTSD.Neurosci Lett. 2017; 649: 181-185
- Reduction of PTSD symptoms with pre-reactivation propranolol therapy: A randomized controlled trial.Am J Psychiatry. 2018; 175: 427-433
- Augmenting treatment efficiency in exposure therapy for PTSD: A randomized double-blind placebo-controlled trial of yohimbine HCl.Cogn Behav Ther. 2018; 47: 351-371
- Response variation following trauma: A translational neuroscience approach to understanding PTSD.Neuron. 2007; 56: 19-32
- Neuroendocrinology of PTSD.in: Nemeroff C.B. Marmar C.R. Post-traumatic Stress Disorder. Oxford, New York2018: 353-374
- The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder.Biol Psychiatry. 2002; 52: 393-403
- Increased adrenocorticotropin suppression following dexamethasone administration in sexually abused adolescents with posttraumatic stress disorder.Psychoneuroendocrinology. 2004; 29: 1281-1289
- Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder.Am J Psychiatry. 1993; 150: 83-86
- Post-traumatic stress disorder.Nat Rev Dis Primers. 2015; 1: 15057
- Endocrine aspects of PTSD: Hypothalamic-pituitary-adrenal (HPA) axis and beyond.in: Martin C.R. Preedy V.R. Patel V.B. Comprehensive Guide to Post-Traumatic Stress Disorders. Springer International, Cham, Switzerland2016: 245-260
- Is there a rationale for cortisol-based treatments for PTSD?.Exp Rev Neurother. 2009; 9: 1113-1115
- Stress effects on memory: An update and integration.Neurosci Biobehav Rev. 2012; 36: 1740-1749
- Stress, glucocorticoids and memory: Implications for treating fear-related disorders.Nat Rev Neurosci. 2017; 18: 7-19
- Post-traumatic stress disorder.N Engl J Med. 2002; 346: 108-114
- A randomized clinical trial of a glucocorticoid receptor antagonist in PTSD.Psychoneuroendocrinology. 2017; 83: 87
- Corticotropin-releasing factor receptor 1 antagonism is ineffective for women with posttraumatic stress disorder.Biol Psychiatry. 2017; 82: 866-874
- The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder and health-related quality of life in survivors.Crit Care Med. 1999; 27: 2678-2683
- Efficacy of hydrocortisone in preventing posttraumatic stress disorder following critical illness and major surgery.Ann N Y Acad Sci. 2006; 1071: 46-53
- High dose hydrocortisone immediately after trauma may alter the trajectory of PTSD: Interplay between clinical and animal studies.Eur Neuropsychopharmacol. 2011; 21: 796-809
- The efficacy of initial hydrocortisone administration at preventing posttraumatic distress in adult trauma patients: A randomized trial.CNS Spectr. 2013; 18: 103-111
- Pharmacological interventions for preventing post-traumatic stress disorder (PTSD).Cochrane Database Syst Rev. 2014; 7: CD006239
- Glucocorticoid augmentation of prolonged exposure therapy: Rationale and case report.Eur J Psychotraumatol. 2010; 1: 5643
- Cortisol augmentation of a psychological treatment for warfighters with posttraumatic stress disorder: Randomized trial showing improved treatment retention and outcome.Psychoneuroendocrinology. 2015; 51: 589-597
- Effects of exogenous glucocorticoid on combat-related PTSD symptoms.Ann Clin Psychiatry. 2010; 22: 274-279
- When translational neuroscience fails in the clinic: Dexamethasone prior to virtual reality exposure therapy increases drop-out rates.J Anxiety Disord. 2019; 61: 89-97
- Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update.Exp Neurol. 2016; 284: 196-210
- Plasma neuropeptide-Y concentrations in humans exposed to military survival training.Biol Psychiatry. 2000; 47: 902-909
- Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD.Biol Psychiatry. 2000; 47: 526-539
- Plasma neuropeptide Y concentrations in combat exposed veterans: Relationship to trauma exposure, recovery from PTSD, and coping.Biol Psychiatry. 2006; 59: 660-663
- Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder.Biol Psychiatry. 2009; 66: 705-707
- Genetic variation in human NPY expression affects stress response and emotion.Nature. 2008; 452: 997-1001
- A randomized dose-ranging study of neuropeptide Y in patients with posttraumatic stress disorder.Int J Neuropsychopharmacol. 2017; 21: 3-11
- Ketamine abuse potential and use disorder.Brain Res Bull. 2016; 126: 68-73
- Antidepressant effects of ketamine in depressed patients.Biol Psychiatry. 2000; 47: 351-354
- A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.Arch Gen Psychiatry. 2006; 63: 856-864
- Antidepressant efficacy of ketamine in treatment-resistant major depression: A two-site randomized controlled trial.Am J Psychiatry. 2013; 170: 1134-1142
- Efficacy and safety of intranasal esketamine adjunctive to oral antidepressant therapy in treatment-resistant depression: A randomized clinical trial.JAMA Psychiatry. 2018; 75: 139-148
- Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression.Biol Psychiatry. 2013; 74: 250-256
- The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?.Pharmacol Ther. 2018; 190: 148-158
- New perspectives in glutamate and anxiety.Pharmacol Biochem Behav. 2012; 100: 752-774
- Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial.Contemp Clin Trials. 2019; 81: 11-18
- Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: A randomized clinical trial.JAMA Psychiatry. 2014; 71: 681-688
- Synaptic loss and the pathophysiology of PTSD: Implications for ketamine as a prototype novel therapeutic.Curr Psychiatry Rep. 2017; 19: 74
- Ketamine treatment and global brain connectivity in major depression.Neuropsychopharmacology. 2017; 42: 1210-1219
- Ketamine, but not the NMDAR antagonist lanicemine, increases prefrontal global connectivity in depressed patients.Chronic Stress. 2018; 2 (2470547018796102)
- PTSD and cognitive symptoms relate to inhibition-related prefrontal activation and functional connectivity.Depress Anxiety. 2017; 34: 427-436
- Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder.J Psychiatr Res. 2013; 47: 1469-1478
- BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls.Neurobiol Stress. 2015; 2: 67-72
- Neurobiology of stress, depression, and rapid acting antidepressants: Remodeling synaptic connections.Depress Anxiety. 2014; 31: 291-296
- Neuronal plasticity and neurotrophic factors in drug responses.Mol Psychiatry. 2017; 22: 1085-1095
- Psychedelics promote structural and functional neural plasticity.Cell Rep. 2018; 23: 3170-3182
- The therapeutic potential of psychedelic drugs: Past, present, and future.Neuropsychopharmacology. 2017; 42: 2105-2113
- The double edged sword of neural plasticity: Increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover.Psychoneuroendocrinology. 2011; 36: 339-351
- Regulating critical period plasticity: Insight from the visual system to fear circuitry for therapeutic interventions.Front Psychiatry. 2013; 4: 146
- The ecstatic history of MDMA: From raving highs to saving lives.in: Breaking Convention Book of Proceedings from the 2013 Conference. Strange Attractor Press, London2015: 87-94
- MDMA enhances emotional empathy and prosocial behavior.Soc Cogn Affect Neurosci. 2013; 9: 1645-1652
- Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy.J Psychopharmacol. 2017; 31: 967-974
- Can drugs be used to enhance the psychotherapeutic process?.Am J Psychother. 1986; 40: 393-404
- The Secret Chief Revealed.Multidisciplinary Association for Psychedelic Studies, Sarasota, FL2004
- Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies.Hum Psychopharmacol. 2001; 16: 589-598
- Oxytocin receptor gene variation predicts subjective responses to MDMA.Soc Neurosci. 2016; 11: 592-599
- MDMA, politics and medical research: Have we thrown the baby out with the bathwater?.J Psychopharmacol. 2007; 21: 787-791
- MDMA as a probe and treatment for social behaviors.Cell. 2016; 166: 269-272
- The safety and efficacy of ±3, 4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: The first randomized controlled pilot study.J Psychopharmacol. 2011; 25: 439-452
- Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3, 4-methylenedioxymethamphetamine-assisted psychotherapy: A prospective long-term follow-up study.J Psychopharmacol. 2013; 27: 28-39
- MDMA-assisted psychotherapy for treatment of PTSD: Study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials [published online ahead of print May 7].Psychopharmacology. 2019;
- MDMA is certainly damaging after 25 years of empirical research: A reply and refutation of Doblin et al.(2014).Hum Psychopharmacol. 2014; 29: 109-119
- The effects of ‘ecstasy’ (MDMA) on visuospatial memory performance: Findings from a systematic review with meta-analyses.Hum Psychopharmacol. 2012; 27: 113-138
- A reconsideration and response to Parrott AC (2013): Human psychobiology of MDMA or ‘Ecstasy’: An overview of 25 years of empirical research.Hum Psychopharmacol. 2014; 29: 105-108
- Retraction. Science. 2003; 301: 1479
- MDMA Investigational Brochure.MAPS, Santa Cruz, CA2017
- Oxytocin-dependent reopening of a social reward learning critical period with MDMA.Nature. 2019; 569: 116-120
- MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms?.Prog Neuropsychopharmacol Biol Psychiatry. 2018; 84: 221-228
- Novel psychopharmacological therapies for psychiatric disorders: Psilocybin and MDMA.Lancet Psychiatry. 2016; 3: 481-488
- Corticotropin-releasing factor type 1 receptor antagonists for stress-related disorders: Time to call it quits?.Biol Psychiatry. 2017; 82: 858-860
- Mechanistic inferences on metabolic dysfunction in PTSD from an integrated model and multi-omic analysis: Role of glucocorticoid receptor sensitivity.Am J Physiol Endocrinol Metab. 2019; ([published online ahead of print Jul 19])
- Epigenome-wide association of Ptsd from heterogeneous cohorts with a common multi-site analysis pipeline.Am J Med Genet B Neuropsychiatr Genet. 2017; 174: 619-630
- Integrating biological treatment mechanisms into randomized clinical trials: Design of PROGrESS (PROlonGed ExpoSure and Sertraline Trial).Contemp Clin Trials. 2018; 64: 128-138
- Association between serotonin transporter gene promoter-region polymorphism and 4-and 12-week treatment response to sertraline in posttraumatic stress disorder.J Affect Disord. 2012; 136: 955-962
- Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.Transl Psychiatry. 2018; 8: 280
- 636,120 Ways to have posttraumatic stress disorder.Perspect Psychol Sci. 2013; 8: 651-662
- The need to take a staging approach to the biological mechanisms of PTSD and its treatment.Curr Psychiatry Rep. 2017; 19: 10
- Emotion regulatory brain function and SSRI treatment in PTSD: Neural correlates and predictors of change.Neuropsychopharmacology. 2016; 41: 611-618
- Stahl's Essential Psychopharmacology: Neuroscientific Basis and Practical Applications.Cambridge University Press, New York2013
Tonix Pharmaceuticals Holding Corp. Tonmya for PTSD. Available at: https://www.tonixpharma.com/pipeline/tonmya-for-ptsd. Accessed December 23, 2018.
- Mirtazapine vs. placebo in posttraumatic stress disorder: A pilot trial.Biol Psychiatry. 2003; 53: 188-191
- An open-label study of mirtazapine as treatment for combat-related PTSD.Ann Pharmacother. 2009; 43: 1220-1226
- Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies.Neurosci Lett. 2017; 649: 147-155
- Nefazodone in post-traumatic stress disorder: Results from six open-label trials.Int Clin Psychopharmacol. 1999; 14: 61-68
- D-cycloserine augmentation of exposure therapy for post-traumatic stress disorder: A pilot randomized clinical trial.Neuropsychopharmacology. 2014; 39: 1052-1058
- A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder.Biol Psychiatry. 2012; 71: 962-968
- A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War veterans.Am J Psychiatry. 2014; 171: 640-648
- Nitrous oxide for treatment-resistant major depression: A proof-of-concept trial.Biol Psychiatry. 2015; 78: 10-18
- Review of the use of the glutamate antagonist riluzole in psychiatric disorders and a description of recent use in childhood obsessive-compulsive disorder.J Chil Adolesc Psychopharmacol. 2010; 20: 309-315
- Neurosteroid biosynthesis down-regulation and changes in GABAA receptor subunit composition: A biomarker axis in stress-induced cognitive and emotional impairment.Br J Pharmacol. 2017; 174: 3226-3241
- The efficacy and tolerability of tiagabine in adult patients with post-traumatic stress disorder.J Clin Psychopharmacol. 2007; 27: 85-88
- Tiagabine for posttraumatic stress disorder: Effects of open-label and double-blind discontinuation treatment.Psychopharmacology. 2006; 184: 21-25
- A randomized controlled trial of ganaxolone in posttraumatic stress disorder.Psychopharmacology. 2017; 234: 2245-2257
- Clinical correlates of DHEA associated with post-traumatic stress disorder.Acta Psychiatr Scand. 2006; 114: 187-193
- Acamprosate for the treatment of alcohol dependence.Clin Ther. 2005; 27: 695-714
- Acamprosate for treatment of alcohol dependence: Mechanisms, efficacy, and clinical utility.Ther Clin Risk Manage. 2012; 8: 45-53
- Guanfacine for PTSD nightmares.J Am Acad Child Adolesc Psychiatry. 1996; 35: 975-976
- Clonidine for posttraumatic stress disorder in preschool children.J Am Acad Child Adolesc Psychiatry. 1996; 35: 1247-1249
- An open-label study of guanfacine extended release for traumatic stress related symptoms in children and adolescents.J Chil Adolesc Psychopharmacol. 2013; 23: 244-251
- Examining the utility of using genotype and functional biology in a clinical pharmacology trial: Pilot testing dopamine β-hydroxylase, norepinephrine, and PTSD.Psychiatr Genet. 2014; 24: 181-182
- A pilot study of mifepristone in combat-related PTSD.Depress Res Treat 2012. 2012; : 393251
- A randomized, double-blind, placebo-controlled, crossover trial of mifepristone in Gulf War veterans with chronic multisymptom illness.Psychoneuroendocrinology. 2016; 64: 22-30
- Cannabidiol as a Therapeutic alternative for post-traumatic stress disorder: From bench research to confirmation in human trials.Front Neurosci. 2018; 12: 502
- Association of in vivo κ-opioid receptor availability and the transdiagnostic dimensional expression of trauma-related psychopathology.JAMA Psychiatry. 2014; 71: 1262-1270
- Buprenorphine for the treatment of posttraumatic stress disorder.Am J Addict. 2019; 28: 86-91
- Enhancing extinction learning in posttraumatic stress disorder with brief daily imaginal exposure and methylene blue: A randomized controlled trial.J Clin Psychiatry. 2017; 78: e782-e789
- A novel V1a receptor antagonist blocks vasopressin-induced changes in the CNS response to emotional stimuli: An fMRI study.Front Syst Neurosci. 2013; 7: 100
- The associations between oxytocin and trauma in humans: A systematic review.Front Pharmacol. 2018; 9: 154
- A selective neurokinin-1 receptor antagonist in chronic PTSD: A randomized, double-blind, placebo-controlled, proof-of-concept trial.Eur Neuropsychopharmacol. 2011; 21: 221-229
- Advances in psychopharmacology for anxiety disorders.Focus. 2014; 12: 152-162
- Interfering with the reconsolidation of traumatic memory: Sirolimus as a novel agent for treating veterans with posttraumatic stress disorder.Ann Clin Psychiatry. 2013; 25: 33-40