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Severe Obsessive-Compulsive Disorder Secondary to Neurodegeneration With Brain Iron Accumulation: Complete Remission After Subthalamic Nuclei Deep Brain Stimulation

  • Suhan Senova
    Affiliations
    Department of Neurosurgery, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Université Paris Est Creteil, Faculté de Médecine, Créteil, France

    Institut Mondor de Recherche Biomédicale University Paris Est Creteil/INSERM U 955 Team 14 Créteil, France
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  • Luc Mallet
    Affiliations
    Department of Psychiatry, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Université Paris Est Creteil, Faculté de Médecine, Créteil, France

    Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Institut du cerveau et de la moelle épinière, Paris, France

    Department of Mental Health and Psychiatry, Global Health Institute, University of Geneva, Geneva, Switzerland
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  • Jean-Marc Gurruchaga
    Affiliations
    Department of Neurosurgery, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Université Paris Est Creteil, Faculté de Médecine, Créteil, France

    Institut Mondor de Recherche Biomédicale University Paris Est Creteil/INSERM U 955 Team 14 Créteil, France
    Search for articles by this author
  • Corentin Rabu
    Affiliations
    Department of Psychiatry, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Université Paris Est Creteil, Faculté de Médecine, Créteil, France
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  • Mathilde Derosin
    Affiliations
    Department of Neurosurgery, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Institut Mondor de Recherche Biomédicale University Paris Est Creteil/INSERM U 955 Team 14 Créteil, France
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  • Jérôme Yelnik
    Affiliations
    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Sorbonne Universités, UPMC Univ Paris 06, CNRS, INSERM, Institut du cerveau et de la moelle épinière, Paris, France
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  • Pierre Brugieres
    Affiliations
    Department of Neuroradiology, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Institut Mondor de Recherche Biomédicale University Paris Est Creteil/INSERM U 955 Team 14 Créteil, France
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  • Antoine Pelissolo
    Affiliations
    Department of Psychiatry, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Université Paris Est Creteil, Faculté de Médecine, Créteil, France

    Institut Mondor de Recherche Biomédicale University Paris Est Creteil/INSERM U 955 Team 14 Créteil, France
    Search for articles by this author
  • Stéphane Palfi
    Affiliations
    Department of Neurosurgery, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Université Paris Est Creteil, Faculté de Médecine, Créteil, France

    Institut Mondor de Recherche Biomédicale University Paris Est Creteil/INSERM U 955 Team 14 Créteil, France
    Search for articles by this author
  • Philippe Domenech
    Correspondence
    Address correspondence to Philippe Domenech, APHP/HU Henri MONDOR Psychiatry, 51 avenue du Maréchal de Lattre de Tassigny, Créteil, Île-de-France 94000, France.
    Affiliations
    Department of Psychiatry, Groupe Hospitalo-Universitaire Henri Mondor, Département Hospitalo-Universitaire Psychiatrie et Neurologie Personnalisées, Créteil, France

    GHU Henri Mondor, DHU PePsy, Psychiatry, Neurosurgery and Neuroradiology Departments, Créteil, France

    Université Paris Est Creteil, Faculté de Médecine, Créteil, France
    Search for articles by this author
      Neurodegeneration with brain iron accumulation (NBIA) is defined as an accumulation of iron in the basal ganglia associated with neurologic and psychiatric symptoms (
      • Hayflick S.J.
      • Westaway S.K.
      • Levinson B.
      • Zhou B.
      • Johnson M.A.
      • Ching K.H.
      • Gitschier J.
      Genetic, clinical, and radiographic delineation of Hallervorden-Spatz syndrome.
      ). Its estimated prevalence is 1:1,000,000 (
      • Schneider S.A.
      • Zorzi G.
      • Nardocci N.
      Pathophysiology and treatment of neurodegeneration with brain iron accumulation in the pediatric population.
      ). Cardinal symptoms include dystonia; spasticity and/or Parkinsonian syndrome, often associated with cognitive decline (
      • Pellecchia M.T.
      • Valente E.M.
      • Cif L.
      • et al.
      The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration.
      ,
      • Thomas M.
      • Hayflick S.J.
      • Jankovic J.
      Clinical heterogeneity of neurodegeneration with brain iron accumulation (Hallervorden-Spatz syndrome) and pantothenate kinase-associated neurodegeneration.
      ); and psychiatric disorders such as obsessive-compulsive disorder (OCD) (
      • Pellecchia M.T.
      • Valente E.M.
      • Cif L.
      • et al.
      The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration.
      ,
      • Nardocci N.
      • Rumi V.
      • Combi M.L.
      • Angelini L.
      • Mirabile D.
      • Bruzzone M.G.
      Complex tics, stereotypies, and compulsive behavior as clinical presentation of a juvenile progressive dystonia suggestive of Hallervorden-Spatz disease.
      ,
      • Nicholas A.P.
      • Earnst K.S.
      • Marson D.C.
      Atypical Hallervorden-Spatz disease with preserved cognition and obtrusive obsessions and compulsions.
      ), depression (
      • Morphy M.A.
      • Feldman J.A.
      • Kılburn G.
      Hallervorden-Spatz disease in psychiatric setting.
      ), or psychosis (
      • Oner O.
      • Oner P.
      • Deda G.
      • Icagasioglu D.
      Psychotic disorder in a case with Hallervorden-Spatz disease.
      ).
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