Disentangling the Effects of Peripheral Inflammatory Markers on Brain Functional Connectivity

  • Neil A. Harrison
    Address correspondence to Neil A. Harrison, M.B.B.S., Ph.D., Cardiff University, Cardiff University Brain Research Imaging Centre, Maindy Road, Cardiff, South Glamorgan CF24 4HQ, United Kingdom.
    Cardiff University Brain Research Imaging Centre, Department of Psychology, Cardiff, United Kingdom

    Division of Psychological Medicine and Neuroscience, Department of Medicine, Cardiff University, Cardiff, United Kingdom
    Search for articles by this author
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Biological Psychiatry
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Bullmore E.
        The Inflamed Mind: A Radical New Approach to Depression.
        Short Books, London2018
        • Savitz J.
        • Harrison N.A.
        Interoception and inflammation in psychiatric disorders.
        Biol Psychiatry Cogn Neurosci Neuroimaging. 2018; 3: 514-524
        • Felger J.C.
        • Li Z.
        • Haroon E.
        • Woolwine B.J.
        • Jung M.Y.
        • Hu X.
        • Miller A.H.
        Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression.
        Mol Psychiatry. 2016; 21: 1358-1365
        • Weber M.D.
        • Godbout J.P.
        • Sheridan J.F.
        Repeated social defeat, neuroinflammation, and behavior: Monocytes carry the signal.
        Neuropsychopharmacology. 2017; 42: 46-61
        • Nusslock R.
        • Brody G.H.
        • Armstrong C.C.
        • Carroll A.L.
        • Sweet L.H.
        • Yu T.
        • et al.
        Higher peripheral inflammatory signaling associated with lower resting-state functional brain connectivity in emotion regulation and central executive networks.
        Biol Psychiatry. 2019; 86: 153-162
        • Khandaker G.M.
        • Pearson R.M.
        • Zammit S.
        • Lewis G.
        • Jones P.B.
        Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: A population-based longitudinal study.
        JAMA Psychiatry. 2014; 71: 1121-1128
        • Filiano A.J.
        • Xu Y.
        • Tustison N.J.
        • Marsh R.L.
        • Baker W.
        • Smirnov I.
        • et al.
        Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour.
        Nature. 2016; 535: 425-429
        • Kraynak T.E.
        • Marsland A.L.
        • Wager T.D.
        • Gianaros P.J.
        Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.
        Neurosci Biobehav Rev. 2018; 94: 76-92
        • Dipasquale O.
        • Cooper E.A.
        • Tibble J.
        • Voon V.
        • Baglio F.
        • Baselli G.
        • et al.
        Interferon-α acutely impairs whole-brain functional connectivity network architecture – A preliminary study.
        Brain Behav Immun. 2016; 58: 31-39
        • Marsland A.L.
        • Kuan D.C.
        • Sheu L.K.
        • Krajina K.
        • Kraynak T.E.
        • Manuck S.B.
        • Gianaros P.J.
        Systemic inflammation and resting state connectivity of the default mode network.
        Brain Behav Immun. 2017; 62: 162-170

      Linked Article