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Will Deep Brain Stimulation Help Move Precision Medicine to the Clinic in Psychiatry?

  • Darin D. Dougherty
    Correspondence
    Address correspondence to Darin D. Dougherty, M.D., M.M.Sc., Department of Psychiatry, Massachusetts General Hospital—East, CNY2612, 149 13th St, Charlestown, MA 02129.
    Affiliations
    Department of Psychiatry, Massachusetts General Hospital, Charlestown, Massachusetts
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      References

        • Tyagi H.
        • Apergis-Schoute A.M.
        • Akram H.
        • Foltynie T.
        • Limousin P.
        • Drummond L.M.
        • et al.
        A randomized trial directly comparing ventral capsule and anteromedial subthalamic nucleus stimulation in obsessive-compulsive disorder: Clinical and imaging evidence for dissociable effects.
        Biol Psychiatry. 2019; 85: 726-734
        • Nuttin B.
        • Cosysns P.
        • Demeulemeester H.
        • Gybels J.
        • Meyerson B.
        Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder.
        Lancet. 1999; 354: 1526
        • Greenberg B.D.
        • Gabriels L.A.
        • Malone Jr., D.A.
        • Rezai A.R.
        • Friehs G.M.
        • Okun M.S.
        • et al.
        Deep brain stimulation of the ventral internal caspule/ventral striatum for obsessive-compulsive disorder: Worldwide experience.
        Mol Psychiatry. 2010; 15: 64-79
        • Mallet L.
        • Polosan M.
        • Jaafari N.
        • Baup N.
        • Welter M.L.
        • Fontaine D.
        • et al.
        Subthalamic nucleus stimulation in severe obsessive-compulsive disorder.
        N Engl J Med. 2008; 359: 2121-2134
        • Mayberg H.S.
        • Lozano A.M.
        • Voon V.
        • McNeely H.E.
        • Seminowicz D.
        • Hamani C.
        • et al.
        Deep brain stimulation for treatment-resistant depression.
        Neuron. 2005; 45: 651-660
        • Malone Jr., D.A.
        • Dougherty D.D.
        • Rezai A.R.
        • Carpenter L.L.
        • Friehs G.M.
        • Eskandar E.N.
        • et al.
        Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression.
        Biol Psychiatry. 2009; 65: 267-275
        • Dougherty D.D.
        • Rezai A.R.
        • Carpenter L.L.
        • Howland R.H.
        • Bhati M.T.
        • O’Reardon J.P.
        • et al.
        A randomized sham-controlled trial of dep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression.
        Biol Psychiatry. 2015; 78: 240-248
        • Holtzheimer P.E.
        • Husain M.M.
        • Lisanby S.H.
        • Taylor S.F.
        • Whitworth L.A.
        • McClintock S.
        • et al.
        Subcallosal cingulate deep brain stimulation for treatment-resistant depression: A multisite, randomised, sham-controlled trial.
        Lancet Psychiatry. 2017; 4: 839-849
        • Widge A.S.
        • Deckersbach T.
        • Eskandar E.N.
        • Dougherty D.D.
        Deep brain stimulation for treatment-resistant psychiatric illness: What has gone wrong and what should we do next?.
        Biol Psychiatry. 2016; 79: e9-e10
        • Widge A.S.
        • Ellard K.K.
        • Paulk A.C.
        • Basu I.
        • Yousefi A.
        • Zorowitz S.
        • et al.
        Treating refractory mental illness with closed-loop brain stimulation: Progress towards a patient-specific transdiagnostic approach.
        Exp Neurol. 2017; 287: 461-472

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