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S32. Therapeutic Potential of Nociceptin/Orphanin Fq (NOP) Receptor Antagonists in a Rodent Model of Traumatic Stress

      Current FDA-approved pharmacotherapies for the treatment of post-traumatic stress disorder (PTSD) are limited in number and efficacy. Recent evidence implicates the nociceptin/orphanin FQ (NOP) receptor system in PTSD. Therefore, NOP antagonists may have therapeutic potential for the treatment of PTSD. Here, we evaluate the efficacy of NOP antagonists to remediate the effects of traumatic stress exposure using preclinical rodent models of traumatic stress exposure and conditioned fear.
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