Current FDA-approved pharmacotherapies for the treatment of post-traumatic stress
disorder (PTSD) are limited in number and efficacy. Recent evidence implicates the
nociceptin/orphanin FQ (NOP) receptor system in PTSD. Therefore, NOP antagonists may
have therapeutic potential for the treatment of PTSD. Here, we evaluate the efficacy
of NOP antagonists to remediate the effects of traumatic stress exposure using preclinical
rodent models of traumatic stress exposure and conditioned fear.
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© 2019 Published by Elsevier Inc.
