S31. Beneficial Effects of FAAH Inhibition on Fear- and Stress-Related Behaviors in Healthy Humans

      The endocannabinoid (eCB) system is proposed to act as a “stress buffer” and thus represents a novel therapeutic target for stress-related psychiatric disorders. Preclinical data suggests that inhibition of fatty acid amide hydrolase (FAAH), the main degradative enzyme of the eCB anandamide (AEA), facilitates fear extinction and protects against the anxiogenic effects of stress. However, no studies have yet assessed whether pharmacological inhibition of FAAH would produce similar effects in humans.
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