F17. Failure to Extinguish Fear in Trauma-Exposed Children With a Common Variant in the Cannabinoid Receptor 1 Gene

      Deficits in fear extinction are implicated in the pathophysiology of anxiety disorders such as posttraumatic stress disorder. Recent studies suggest that signaling via the cannabinoid receptor 1 (CB1R) is essential for fear extinction. A common variant in the gene encoding the CB1R (CNR1) has been linked to poor extinction learning in adults. However, anxiety disorders typically begin in childhood. The present study examines the effect of CNR1 on fear extinction learning and its later recall in children.
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