Deficits in fear extinction are implicated in the pathophysiology of anxiety disorders
such as posttraumatic stress disorder. Recent studies suggest that signaling via the
cannabinoid receptor 1 (CB1R) is essential for fear extinction. A common variant in
the gene encoding the CB1R (CNR1) has been linked to poor extinction learning in adults.
However, anxiety disorders typically begin in childhood. The present study examines
the effect of CNR1 on fear extinction learning and its later recall in children.
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© 2019 Published by Elsevier Inc.
