Long-term AIDS Survivors (LTAS) are people with HIV diagnosed prior to the advent
of antiretroviral therapy. LTAS suffer high rates of multiple psychiatric illnesses;
demoralization is a syndrome common in LTAS and is characterized by a sense of helplessness,
hopelessness, and a loss of meaning and purpose in life. Psilocybin is a 5HT2A agonist
and classic psychedelic that can improve depression and anxiety in cancer patients
when combined with individual psychotherapy, possibly by decreasing demoralization.
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