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O53. Maternal Immune Activation Induced Structural Brain Alterations in Macaques: A Longitudinal Study

      The impact of maternal immune activation (MIA) on neurodevelopment has been widely studied in rodents. However, only two non-human primate (NHP) neuroimaging studies have been reported. Viral MIA caused reduction of grey and white matter while bacterial MIA was associated with enlargement of brain structures at 12 months. In a pilot study, MIA NHP’s showed typical early development with behavioral changes after 2 years. Here, we investigated brain structural alterations associated with MIA in a new sample of NHP’s using a longitudinal neuroimaging design.
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