O51. Beyond C4: Analysis of the Complement Gene Pathway Shows Enrichment for IQ in Patients With Schizophrenia and Healthy Controls

      In multiple Genome wide Association Studies (GWAS) of Schizophrenia (SZ), the strongest association with SZ has consistently been found at the major histocompatibility complex - a region synonymous with immune function. Variation in cognitive performance, which is strongly predictive of functional outcome in SZ, is explained by several variants at this locus related to the complement system, including complement C4. Here, we analyse the effects of genes related to complement, and whether these are enriched for IQ or SZ risk.
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